Article: Immunoscintigraphy of the bone marrow: Normal uptake values of technetium-99m-labeled monoclonal antigranulocyte antibodies

The aim of our study was to determine the normal range of the 99mTc-labeled anti-NCA 95 antigranulocyte antibody (AGAb) uptake in the bone marrow using the sacroiliac-to-background uptake ratio in the posterior view. Methods: We made 169 planar bone marrow scans on 162 patients who were each injected with 555 MBq AGAb. Fifty patients with the diagnosis of infection/pyrexia of unknown origin (PUO) and with completely normal bone marrow scintigraphy were defined as the normal group. Uptake ratios were calculated drawing irregular regions of interest around the sacroiliac and a background area, respectively. Results: The normal group revealed a mean uptake ratio of 7.3 + 2.3 (range 4.4-12.6). ...

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