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Comparison of bone marrow toxicity of medium-chain and long-chain triglyceride emulsions: An in vitro study in humans

PHILIPPE BEAU, MD*; PAUL REGIS MANNANT, MD*; DANI*LE PELLEIERt; AND ANDRP BRIZARD, MD, PHDt From the *Gastroenterology and Nutritional Support Unit and tHematology Laboratory, University Hospital, Poitiers, France

ABSTRACT. Background: In this study, we evaluated the in vitro bone marrow toxicity of two lipid emulsions containing either long-chain triglycerides (LCT) or a mixture of medium-chain triglycerides (MCT) and LCT. Methods: Bone marrow cells were obtained from six healthy subjects and were cultured for 14 days after a 24-hour preincubation with various concentrations (from 0 to 10 mg/mL) of LCT- and LCT/MCT-based lipid emulsions. Results: Compared with controls (no preincubation ...

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