Article: Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG

Abstract: The aim of this study was to determine the best method to evaluate the QT interval with respect to the heart rate in rhesus monkeys. Rhesus monkeys (Macaca mulatta) are widely used in cardiovascular research, but the characteristics of QT-RR formulas as regards rhesus monkeys has not been sufficiently related. We analyzed the physiological QT-RR relation for practical evaluation of the QT interval in conscious rhesus monkeys by use of 24-h Holter ECG monitoring. As the QT interval varies with dependency on the RR interval, 14 QT regression functions were evaluated by use of about 50 pairs of QT-RR points per animal in 5 male rhesus monkeys. The accuracy of fit with the measured ...

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