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Article: Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation
- Article from:
- The Journal of Nutrition
- Article date:
- November 1, 2002
- Author:
CopyrightCopyright American Institute of Nutrition Nov 2002. Provided by ProQuest LLC. (Hide copyright information)
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Biochemical and Molecular Actions of Nutrients
ABSTRACT Marginal intake of zinc and vitamin A is common during lactation and a deficiency of one micronutrient can result in a secondary deficiency of the other. However, the resistance of milk zinc (Zn) concentration to changes in dietary Zn or vitamin A indicates tight regulation of mammary gland Zn transport. Although several mammalian proteins have been identified and implicated in Zn transport, the mechanisms responsible for mammary gland Zn transport and their regulation by dietary Zn and vitamin A are unknown. In this study, we identified mammary gland Zn transporters and determined effects of marginal Zn and vitamin A intakes on their ...