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Article: Omega-3 fatty acids to augment cancer therapy
- Article from:
- The Journal of Nutrition
- Article date:
- November 1, 2002
- Author:
CopyrightCopyright American Institute of Nutrition Nov 2002. Provided by ProQuest LLC. (Hide copyright information)
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Omega-3 Fatty Acids to Augment Cancer Therapy1
ABSTRACT The results of animal studies have demonstrated that the consumption of omega-3 fatty acids can slow the growth of cancer xenografts, increase the efficacy of chemotherapy and reduce the side effects of the chemotherapy or of the cancer. Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include 1) suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor; 2) decreasing the expression of AP-1 and ras, two oncogenes implicated in tumor promotion; 3) inducing differentiation of cancer cells; 4) suppressing ...