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Article: Regional lumped constant differences and asymmetry in fluorine-18-FDG uptake in temporal lobe epilepsy
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- January 1, 1998
- Author:
CopyrightCopyright Society of Nuclear Medicine Jan 1998. Provided by ProQuest LLC. (Hide copyright information)
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To date, there has been no satisfactory explanation for the observation that interictal uptake of the glucose analog [^sup 18^F]fluorodeoxyglucose (FDG) is consistently reduced in the temporal lobe ipsilateral to the seizure focus in patients with temporal lobe epilepsy. We examined the hypothesis that regional differences in tracer uptake in temporal lobe epilepsy reflect regional differences in the lumped constant (A). Methods: In 9 control subjects and 10 patients with temporal lobe epilepsy, we obtained regional estimates of A by expressing A in terms of transfer coefficients for FDG and parameters which are likely to remain constant throughout both the brain and under different ...