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Article: Reduced food intake in zinc deficient rats is normalized by megestrol acetate buy not by insulin-like growth factor-I
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 1998
- Author:
CopyrightCopyright American Institute of Nutrition Jan 1998. Provided by ProQuest LLC. (Hide copyright information)
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Reduced Food Intake in Zinc Deficient Rats Is Normalized by Megestrol Acetate but not by Insulin-Like Growth Factor-1,2
J. D. Browning,* R. S. MacDonald,^ W. H. Thornton^ and B. L. O'Dell*3
ABSTRACT Zinc deficiency in rats results in impaired growth accompanied by decreased and cyclic food intake. These signs are associated with decreased plasma insulin-like growth factor-I (IGF-I), a major mediator of growth. The purpose of this study was to determine the relationship between decreased plasma IGF-I and the impairment of appetite and growth in zinc deficiency. Immature male rats were fed free choice a low zinc (<1 mg/kg) diet (-Zn) or a zinc adequate (100 mg/kg) control diet (+Zn). ...