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Article: Clinical effects of grapefruit juice-nifedipine interaction in a 54-year-old Nigerian: A case report
- Article from:
- Journal of the National Medical Association
- Article date:
- April 1, 2002
- Author:
CopyrightCopyright National Medical Association Apr 2002. Provided by ProQuest LLC. (Hide copyright information)
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C A S E R E P O R T
Grapefruit juice is known to increase the oral bioavailability of dihydropyridine calcium channel blockers, including nifedipine, by reducing presystemic clearance. The nature and magnitude of this interaction has not been studied in black Africans. Previous studies have reported reduced systemic clearance of nifedipine in this population, suggesting altered risk from the interaction of grapefruit juice and nifedipine. We report a case of a nifedipine-grapefruit juice adverse interaction in a Nigerian to draw attention to the problem and further sensitize practitioners. (J Natl Med Assoc. 2002;94:276-278.)
Key words: grapefruit juice * nifedipine * black Africans
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