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Multiple regions of RyR1 mediate functional and structural interactions with (alpha)(1S)-dihydropyridine receptors in skeletal muscle
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Biophysical Journal
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December 1, 2002
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Copyright informationCopyright Biophysical Society Dec 2002. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT Excitation-contraction (e-c) coupling in muscle relies on the interaction between dihydropyridine receptors (DHPRs) and RyRs within Ca^sup 2+^ release units (CRUs). In skeletal muscle this interaction is bidirectional: alpha^sub 1S^DHPRs trigger RyR1 (the skeletal form of the ryanodine receptor) to release Ca^sup 2+^ in the absence of Ca2+ permeation through the DHPR, and RyRls, in turn, affect the open probability of alpha^sub 1S^DHPRs. alpha^sub 1S^DHPR and RyR1 are linked to each other, organizing alpha^sub 1S^DHPRs into groups of four, or tetrads. In cardiac muscle, however, alpha^sub 1C^DHPR Ca^sup 2+^ current is important for activation of RyR2 (the cardiac isoform of the ...
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