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Article: Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Jan 2003. Provided by ProQuest LLC. (Hide copyright information)
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Biochemical and Molecular Actions of Nutrients Research Communication
Copper Deficiency Induces the Upregulation of the Copper Chaperone for Cu/Zn Superoxide Dismutase in Weanling Male Rats1
(Manuscript received 7 August 2002. Initial review completed 27 August 2002. Revision accepted 23 October 2002.)
ABSTRACT The most commonly used indices for determining copper deficiency in humans are reduced serum/ plasma copper concentration and decreased activity of ceruloplasmin and Cu/Zn superoxide dismutase (SOD1). However, these indicators are influenced by many factors unrelated to copper status and lack the sensitivity required to detect marginal deficiency, limiting their usefulness in many ...