Article: Absorption and conversion of 11,12-(3)H-(beta)-carotene to vitamin A in Sprague-Dawley rats of different vitamin A status

Nutrient Metabolism

Absorption and Conversion of 11,12-^sup 3^H-beta-Carotene to Vitamin A in Sprague-Dawley Rats of Different Vitamin A Status1,2

ABSTRACT The aim of this study was to determine the bioavailability and bioconversion to vitamin A of a single oral dose in oil or an aqueous dispersion of labeled beta-carotene in rats of different vitamin A status. Weanling Sprague-Dawley rats were fed a vitamin A-deficient diet and supplemented for 4 wk with 0, 7, 21 and 63 (mu)g/(rat * d) of retinyl acetate. The rats, of different vitamin A status, were then given a single oral dose of 11,12-^sup 3^H--beta-carotene (0.15 (mu)mol) dissolved in corn oil or dispersed in aqueous Tween 80. The ...

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