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Article: Retinoid target gene activation during induced tumor cell differentiation: Human embryonal carcinoma as a model
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Jan 2003. Provided by ProQuest LLC. (Hide copyright information)
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Symposium: Advances in Retinoid Research: Mechanisms of Cancer Chemoprevention
Retinoid Target Gene Activation during Induced Tumor Cell Differentiation: Human Embryonal Carcinoma as a Model1,2
ABSTRACT Many agents that exhibit chemopreventive activity are able to mediate a differentiation response in premalignant and malignant tissues. One of the most widely studied classes of tumor differentiation agents is the retinoids. There is rapidly evolving evidence for beneficial retinoid actions in the prevention or treatment of clinical tumors. However, the use of retinoids in the clinic is limited by acquired resistance and toxicity, especially when administered chronically in preventive ...