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Article: Mammalian zinc transporters
- Article from:
- The Journal of Nutrition
- Article date:
- April 1, 1998
- Author:
CopyrightCopyright American Institute of Nutrition Apr 1998. Provided by ProQuest LLC. (Hide copyright information)
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Mammalian Zinc Transporters 1'2
ABSTRACT Genes that are involved in mammalian zinc transport recently have been cloned. These all predict proteins with multiple membrane spanning regions, and most have a histidine-rich intracellular loop. ZnT-1 was the first cloned and is associated with zinc efflux. It is found in all tissues examined, and, at least in some, ZnT-1 expression is regulated by dietary zinc intake. In enterocytes of the small intestine and renal tubular cells, ZnT-1 is localized to the basolateral membrane, suggesting an orientation that is consistent with zinc absorption/retention. ZnT-2 is also an exporter and may be involved in zinc efflux or uptake into vesicles in ...