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Article: The link between ion permeation and inactivation gating of Kv4 potassium channels
- Article from:
- Biophysical Journal
- Article date:
- February 1, 2003
- Author:
CopyrightCopyright Biophysical Society Feb 2003. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT Kv4 potassium channels undergo rapid inactivation but do not seem to exhibit the classical N-type and C-type mechanisms present in other Kv channels. We have previously hypothesized that Kv4 channels preferentially inactivate from the preopen closed state, which involves regions of the channel that contribute to the internal vestibule of the pore. To further test this hypothesis, we have examined the effects of permeant ions on gating of three Kv4 channels (Kv4.1, Kv4.2, and Kv4.3) expressed in Xenopus oocytes. Rb^sup +^ is an excellent tool for this purpose because its prolonged residency time in the pore delays K^sup +^ channel closing. The data showed that, only when Rb+ carried ...
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