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Article: Vitamin D receptor (VDR) knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin D(9k) mRNA
- Article from:
- The Journal of Nutrition
- Article date:
- February 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Feb 2003. Provided by ProQuest LLC. (Hide copyright information)
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Nutrient-Gene Interactions
Vitamin D Receptor (VDR) Knockout Mice Reveal VDR-Independent Regulation of Intestinal Calcium Absorption and ECaC2 and Calbindin D^sub 9k^ mRNA1,2
ABSTRACT To study the role of calbindin D^sub 9k^ (CaBP) and epithelial calcium channel ECaC2 in intestinal calcium (Ca) absorption, vitamin D receptor knockout (KO) and wild-type (WT) mice were fed either 0.5% Ca or a 2.0% Ca rescue diet starting at 21 d of age. Ca absorption and parameters involved in this process were measured at 60 or 90 d of age. Compared with WT, KO mice fed the 0.5% Ca diet had higher plasma parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D^sub 3^ [1,25(OH)^sub 2^D^sub 3^], and lower ...