Article: Metallothionein Knockout and Transgenic Mice Exhibit Altered Intestinal Processing of Zinc with Uniform Zinc-Dependent Zinc Transporter-1 Expression

Metallothionein Knockout and Transgenic Mice Exhibit Altered Intestinal Processing of Zinc with Uniform Zinc-Dependent Zinc Transporter-1 Expression1,2

Steven R. Davis, Robert J. McMahon and Robert J. Cousins3

ABSTRACT A role for metallothionein in intestinal zinc absorption has been the subject of considerable debate. If metallothionein affects zinc absorption, then those factors that induce metallothionein synthesis (e.g., heavy metals, hormones) should alter zinc absorption and homeostasis. The present studies used metallothionein transgenic mice (overexpressing) and metallothionein knockout mice (no expression of metallothionein-1 or metallothionein-2) to examine directly the effects ...

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