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Article: Ascorbic Acid Deficiency Changes Hepatic Gene Expression of Acute Phase Proteins in Scurvy-Prone ODS Rats
- Article from:
- The Journal of Nutrition
- Article date:
- May 1, 1998
- Author:
CopyrightCopyright American Institute of Nutrition May 1998. Provided by ProQuest LLC. (Hide copyright information)
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Ascorbic Acid Deficiency Changes Hepatic Gene Expression of Acute Phase Proteins in Scurvy-Prone ODS Rats1; Saiko Ikeda,3 Fumihiko Horio4 and Atsushi Kakinuma
ABSTRACT The ODS rat (genotype od/od), which has a hereditary defect in ascorbic acid biosynthesis, was used to investigate the effects of ascorbic acid deficiency on the hepatic gene expression of both the positive acute phase proteins, haptoglobin and a,-acid glycoprotein, and the negative acute phase proteins, apolipoprotein A-I and albumin. Male ODS rats (6 wk old, body weight -140 g) were fed a basal diet containing ascorbic acid (300 mg/kg diet) or a diet without ascorbic acid for 14 d. Ascorbic acid deficiency significantly ...