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Article: HLA antigen profile in pulmonary tuberculosis patients & their spouses
- Article from:
- Indian Journal of Medical Research
- Article date:
- April 1, 1998
- Author:
CopyrightCopyright Indian Council of Medical Research Apr 1998. Provided by ProQuest LLC. (Hide copyright information)
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HLA-A, -B, -DR and -DQ antigen profile was studied in pulmonary tuberculosis patients (n=209) and their spouses (family contacts; n=50) and healthy volunteers (n=72). An increased frequency of HLAA-10, B7, B15, DR2 and DQi was seen in the pulmonary-TB (PTB) patients when compared to the total control subjects (n=122). However, a significant increase was seen only with HLA-DR2 (P < 0.001; Pc < 0.01; Relative Risk 2.3) and -DQ1 (P < 0.005; Pc<0.015; Relative Risk 2.8). Among the spouses and the corresponding patients, a similar increase of HLA-DR2 was seen. A decreased frequency of HLA-A19, B8, B17, B35, DRS and DR6 were seen in PTB as compared to control groups. The present study ...