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New antibody further demarcates chronic, acute urticaria

Research may lead to plasmapheresis, cyclosporine, and IV immunoglobulin therapies

CHARLESTON, S.C. - Recent research shows that a pathogenic, circulating autoantibody is present in up to one-half of patients with chronic urticaria. This finding has led, in turn, to the investigation of three promising new therapies for this difficult-totreat disorder.

Investigators have found that an antireceptor antibody to IgE alpha receptors is present in up to 50 percent of otherwise healthy patients with unexplained chronic urticaria, according to Allen P. Kaplan, M.D., co-director of the Asthma and Allergy Center, Medical University of South Carolina, Charleston.

"We found that the sera of chronic ...

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