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Article: Photochemistry and phototoxicity of aloe emodin

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Photochemistry and Photobiology
Article date:
April 1, 2002
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Photochemistry and Phototoxicity of Aloe Emodin(para)

ABSTRACT

Photochemical pathways leading to the phototoxicity of the aloe vera constituent aloe emodin were studied. The results indicate a photochemical mechanism involving singlet oxygen to be the most likely pathway responsible for the observed phototoxicity. Aloe emodin was found to efficiently generate singlet oxygen when irradiated with UV light (phi^sub Delta^ = 0.56 in acetonitrile). The survival of human skin fibroblast cells in the presence of aloe emodin was found to decrease upon irradiation with UV light. A further decrease in cell survival was observed in D^sub 2^O compared with H2O, suggesting the involvement of singlet ...

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