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Article: The role of the peripheral benzodiazepine receptor in photodynamic activity of certain pyropheophorbide ether photosensitizers: Albumin site II as a surrogate market for activity
- Article from:
- Photochemistry and Photobiology
- Article date:
- July 1, 2002
- Author:
CopyrightCopyright American Society of Photobiology Jul 2002. Provided by ProQuest LLC. (Hide copyright information)
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The Role of the Peripheral Benzodiazepine Receptor in Photodynamic Activity of Certain Pyropheophorbide Ether Photosensitizers: Albumin Site II as a Surrogate Marker for Activity(para)
ABSTRACT
A study has been carried out to define the importance of the peripheral benzodiazepine receptor (PBR) as a binding site for a series of chlorin-type photosensitizers, pyropheophorbide-a ethers, the subject of a previous quantitative structure-activity relationship study by us. The effects of the PBR ligand PK11195 on the photodynamic activity have been determined in vivo for certain members of this series of alkyl-substituted ethers: two of the most active derivatives (hexyl and heptyl), the least ...