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Article: A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer
- Article from:
- Climacteric
- Article date:
- March 1, 2003
- Author:
CopyrightCopyright CRC Press Mar 2003. Provided by ProQuest LLC. (Hide copyright information)
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Key words: VAGINAL ESTROGEN, BREAST CANCER
ABSTRACT
Objective To estimate the risk of recurrence of breast cancer associated with the use of topical vaginal estrogen therapy in the management of vaginal atrophy in women previously treated for breast cancer.
Methods The study group comprised 1472 women with histologically confirmed breast cancer. In 69 of these subjects (4.7%) their only bothersome menopausal problems were vaginal symptoms. In these women, poorly absorbed topical vaginal estrogen cream or tablets were used. The response of these patients was compared with that of the rest of the database. A Cox regression analysis was performed using sex hormone usage after diagnosis as a ...