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Article: Expression of basic fibroblast growth factor in nasal polyps
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- October 1, 1998
- Author:
CopyrightCopyright Annals Publishing Company Oct 1998. Provided by ProQuest LLC. (Hide copyright information)
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Basic fibroblast growth factor (bFGF) is a polypeptide that is mitogenic for a wide variety of cell types. We used Northern blot analysis and immunohistochemistry to determine if bFGF is expressed in the nasal polyp tissue; bFGF messenger RNA was detectable in the polyps examined by Northern blot analysis. Strong immunostaining for bFGF was found in blood vessels and along the basement membrane of the epithelial cell layers. Basal epithelial cells and some infiltrating mononuclear cells also stained for bFGF. Proliferating cell nuclear antigen colocalized with bFGF to basal epithelial cells, endothelial cells, and areas of focal epithelial metaplasia. The polyp tissue was double-labeled ...