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Article: Enhancement of the dissolution rate and bioavailability of glipizide through cyclodextrin inclusion complex
- Article from:
- Pharmaceutical Technology
- Article date:
- June 1, 2003
- Author:
CopyrightCopyright Advanstar Communications, Inc. Jun 2003. Provided by ProQuest LLC. (Hide copyright information)
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Glipizide (GZ) is a widely used oral hypoglycemic drug with very poor water solubility. The purpose of this study was to enhance the dissolution rate and bioavailability of this drug. To study the in vivo bioavailability, three formulations were administered in suspension form to three groups of mice. The results revealed a significant decrease in glucose levels with the formulation containing the GZ-[beta]-CD complex with NaCMC. Also, a good in vivo-in vitro correlation was detected among the three formulations.
Glipizide (GZ) is a second-generation sulfonylurea that can acutely lower the blood glucose level in humans by stimulating the release of insulin from the pancreas and is typically ...