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Article: Amino acid pharmacokinetics and safety assessment1
- Article from:
- The Journal of Nutrition
- Article date:
- June 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Jun 2003. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT Tracer kinetic studies of amino acid metabolism during periods of high amino acid intake should allow insights into adaptive or maladaptive regulatory mechanisms controlling amino acid catabolic or disposal events before clinically evident effects. The principles of amino acid tracer kinetics have been well defined, but their application to establishing upper safe intake levels has been essentially nonexistent. Similarly, the pharmacology field has well-established disciplines of toxicokinetics (the relationship of toxicant dose and delivery to its site of action) and toxicodynamics (the relationship of toxicant at its site of action and downstream functional consequences), but ...