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Article: Basic fibroblast growth factor regulates extracellular matrix and contractile protein expression independent of proliferation in vascular smooth muscle cells
- Article from:
- In Vitro Cellular & Developmental Biology
- Article date:
- April 1, 1998
- Author:
CopyrightCopyright Society for In Vitro Biology Apr 1998. Provided by ProQuest LLC. (Hide copyright information)
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SEIYA KATO, AKIHIKO MURAISHI, TETSUYA MIYAMOTO, AND JONATHAN C. FOX,
SUMMARY
Basic fibroblast growth factor (bFGF) can influence proliferation and differentiation in vascular smooth muscle cells. Basic FGF promotes some features of the synthetic phenotype (proliferation) but is known to inhibit others (collagen synthesis). Whether bFGF availability influences smooth muscle cell phenotype independent of proliferation is not known. The purpose of this study was to determine if the effects of bFGF on extracellular matrix and contractile protein expression are dependent on changes in proliferation. Basic FGF availability was manipulated by adding bFGF to cultured cells or by inhibiting bFGF ...