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Article: Effects of a carane derivative local anesthetic on a phospholipid bilayer studied by molecular dynamics simulation
- Article from:
- Biophysical Journal
- Article date:
- August 1, 2003
- Author:
CopyrightCopyright Biophysical Society Aug 2003. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT Molecular dynamics (MD) simulations of two hydrated palmitoyloleoylphosphatidylcholine (POPC) bilayers each containing eight carane derivative (KP-23) local anesthetic (LA) molecules in neutral (POPC-LA) or protonated (POPC-LAH) forms were carried out to investigate the effect of KP-23 and its protonation on the bilayer. 3-ns trajectories were used for analyses. A pure POPC bilayer was employed as a reference system. In both POPC-LA and POPC-LAH systems a few KP-23 molecules intercalated into the bilayer and moved near the bilayer/water interface. They were located on the hydrophobic core side of the interface in the POPC-LA bilayer, but on the water phase side in the POPC-LAH ...
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