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Article: Marginal biotin deficiency is teratogenic in ICR mice1,2
- Article from:
- The Journal of Nutrition
- Article date:
- August 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Aug 2003. Provided by ProQuest LLC. (Hide copyright information)
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Manuscript received 6 February 2003. Initial review completed 7 April 2003. Revision accepted 5 May 2003.
ABSTRACT The incidence of marginal biotin deficiency in normal human gestation is approximately one in three. In ICR mice, maternal biotin deficiency results in cleft palate, micrognathia, microglossia and limb hypoplasia. However, the relationships among the severity of maternal biotin deficiency, fetal biotin status and malformations have not been reported. This study utilized validated indices of biotin status to investigate the relationships among maternal biotin status, fetal biotin status and the rate of fetal malformations in ICR mice. Biotin status was controlled by feeding ...