Article: Flow cytometric immunophenotyping of bone marrow core biopsies: Report of 8 patients with previously undiagnosed hematologic malignancy and failed bone marrow aspiration

* Objective: To report a method for flow cytometric immunophenotyping (FCI) bone marrow (BM) core biopsies in patients with hematologic malignancies of the BM who present with a failed BM aspiration ("dry tap").

Design and Setting.-Core biopsy specimens of BM were obtained from 8 patients who presented with previously undiagnosed hematologic malignancies arising in (7 cases) or secondarily involving (1 case) the BM and a dry tap. Suspensions of the BM core biopsy specimens were prepared and analyzed by FCI methods.

Data Extraction and Data Synthesis.-The FCI data were

analyzed in conjunction with cytomorphologic, histologic, immunohistochemical, and cytogenetic findings in all cases to ...

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