Articles > Journals > Medical journals > The Journal of Nuclear Medicine articles > March 1999

Article: (18 F) (alpha)-methyl tyrosine PET studies in patients with brain tumors

Article from:
The Journal of Nuclear Medicine
Article date:
March 1, 1999
Author:
Copyright

We have developed '8F-labeled oz-methyl tyrosine (FMT) for PET imaging. The aim of this study was to evaluate the clinical application potential of FMT for patients with brain tumors. Methods: Eleven healthy volunteers and 20 patients with brain tumors were injected with 185 MBq (5 mCi) FMT. In 3 healthy volunteers, whole-body imaging and urinary and plasma analysis were conducted for the assessment of the biodistribution of FMT. The normal range of cortical standardized uptake value (SUV) as a reference for comparing tumor SUV of FMT was estimated by using PET data obtained at 30 min postinjection in 8 healthy volunteers. Dynamic PET scans were conducted for 100 min in 4 healthy volunteers ...

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