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Article: Cholecystokinin-A receptors are involved in food intake suppression in rats after intake of all fats and carbohydrates tested1,2
- Article from:
- The Journal of Nutrition
- Article date:
- July 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Jul 2003. Provided by ProQuest LLC. (Hide copyright information)
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Manuscript received 20 December 2002. Initial review completed January 2003. Revision accepted 29 March 2002 .
ABSTRACT The hypothesis of these studies was that all fats and carbohydrates suppress food intake, at least in part, via cholecystokinin-A receptors (CCKAR). Fat (coconut oil, beef tallow, olive and safflower oil) and carbohydrate (cornstarch, sucrose, glucose and fructose) preloads were given intragastrically (1 g/4 mL) 30 min before feeding. Devazepide (0.25 mg/kg), a CCKAR antagonist, was given intraperitoneally at 60 or 30 min before or with each of the macronutrient preloads. Devazepide reversed food intake suppression caused by all fat and carbohydrate sources, but the effect ...