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Article: Threonine deprivation rapidly activates the system A amino acid transporter in primary cultures of rat neurons from the essential amino acid sensor in the anterior piriform cortex1,2
- Article from:
- The Journal of Nutrition
- Article date:
- July 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Jul 2003. Provided by ProQuest LLC. (Hide copyright information)
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Manuscript received 10 January 2003. Initial review completed 22 February 2003. Revision accepted 7 April 2003.
ABSTRACT Omnivores show recognition of essential (indispensable) amino acid deficiency by changing their feeding behavior within 20 min, yet the cellular mechanisms of amino acid sensation in eukaryotes are poorly understood. The anterior piriform cortex (APC) of the brain in rats or its analog in birds likely houses the in vivo amino acid chemosensor. Because amino acid transporters adapt rapidly to essential amino acid deficiency in several cell models, we hypothesized that activation of electrogenic amino acid transport in APC neurons might contribute to the function of the ...