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Article: Vitamin D-3 receptor as a target for breast cancer prevention1,2
- Article from:
- The Journal of Nutrition
- Article date:
- July 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Jul 2003. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT The vitamin D-3 receptor (VDR) is a nuclear receptor that modulates gene expression when complexed with its ligand 1 -[alpha],25-dihydroxycholecalciferol [1,25(OH)^sub 2^-D^sub 3^], which is the biologically active form of vitamin D-3. The cellular effects of VDR signaling include growth arrest, differentiation and/or induction of apoptosis, which indicate that the vitamin D pathway participates in negative-growth regulation. Although much attention has been directed in recent years toward the development of synthetic vitamin D analogs as therapeutic agents for a variety of human cancers including those derived from the mammary gland, studies on vitamin D as a chemopreventive agent ...