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Article: Technetium HMPAO SPECT study in dementia with Lewy bodies, Alzheimer's disease and idiopathic parkinson's disease
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- June 1, 1999
- Author:
CopyrightCopyright Society of Nuclear Medicine Jun 1999. Provided by ProQuest LLC. (Hide copyright information)
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The aim of this study was to compare the regional cerebral blood flow measurements studied by SPECT in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) to determine the contribution of SPECT to the differential diagnosis of these two diseases. Methods: SPECT analysis with ^sup 99m^Tc-hexamethyl propyleneamine oxime (HMPAO) was performed in 20 patients with probable DLB, 20 patients with probable AD and 20 patients with idiopathic Parkinson's disease (IPD). Ten pairs of regions of interest were analyzed. Tracer uptake was expressed as a corticocerebellar activity ratio. Results: Compared with IPD, in the DLB group there was a global decrease of HMPAO uptake in cortical regions of ...
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