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Article: Prevalence and role of methylenetetrahydrofolate reductase 677 C[arrow right]T and 1298 A[arrow right]C polymorphisms in coronary artery disease in Arabs
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- October 1, 2003
- Author:
CopyrightCopyright College of American Pathologists Oct 2003. Provided by ProQuest LLC. (Hide copyright information)
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* Context.-Previous studies reported an association of 677 C[arrow right]T and 1298 A[arrow right]C methylenetetrahydrofolate reductase (MTHFR) variants with coronary artery disease (CAD). No previous studies concerning the prevalence of these 2 MTHFR variants or their possible association with CAD in Arabs are currently available in the literature.
Objective.-To determine the prevalence of MTHFR variants and their potential relevance to CAD among Arabs.
Design.-We used polymerase chain reaction and restriction enzyme digestion to determine the prevalence of these 2 MTHFR polymorphisms in 625 healthy blood donors (BDs) and 545 angiographically confirmed CAD patients of Arab origin.
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