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Article: Trophic effects of vanadium on beta-cells of STZ-induced insulin dependent diabetic rats & evidence for long term relief of diabetes mellitus
- Article from:
- Indian Journal of Medical Research
- Article date:
- August 1, 1999
- Author:
CopyrightCopyright Indian Council of Medical Research Aug 1999. Provided by ProQuest LLC. (Hide copyright information)
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Accepted August 18, 1999
The effects of one year combined vanadium and insulin treatment (VIT) on. blood glucose levels of insulin dependent diabetic (IDD) rats were studied. Rats made diabetic by an iv injection of 55-60 mg/kg streptozotocin (STZ), divided into two groups and treated with a low dose of NPH insulin (2-4 U/rat) for two months to survive from hyperglycaemic shock. In group A, hyperglycaemia ameliorated during one year by increasing the daily dose of insulin to 8.2 +/- 0.4 U/100 g (IT) and in group B by switching over to hydrated vanadium solution (I mg/ ml vanadyl oxide sulphate pentahydrate in drinking water; VIT). The results of the study indicated that one year VIT ...