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Article: Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon1,2
- Article from:
- The Journal of Nutrition
- Article date:
- October 1, 2003
- Author:
CopyrightCopyright American Institute of Nutrition Oct 2003. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT In humans, colonic bacteria ferment unabsorbed carbohydrates, producing the SCFA acetic, propionic and n-butyric acids. To test for interactions among the SCFA that may affect their absorption, healthy subjects (n = 10) were given 300-mL rectal infusions containing acetate (60 mmol/L), propionate (20 mmol/L) and butyrate (20 mmol/L), alone or in combinations of two or three. The solutions were retained for 30 min, and then subjects voided a sample for SCFA measurement. To examine the relationship between absorption and fecal SCFA concentrations, a fecal sample was collected at the end of the study. The mean percentage of butyrate absorption (30.2 + or - 4.6%) exceeded that of ...