Article: Transgenic protein production: Part 3, nuclear transfer technology

The birth of Dolly the sheep was one of the widely reported biotechnology stories of the decade. This third article in our series covering transgenic technology, analyzes the potential commercial impact that nuclear transfer technology, which created Dolly, may have on the production of proteins in transgenic livestock.

Milk from transgenic livestock offers a commercially viable source for the production of pharmaceutical and nutritionally valuable proteins and peptides. High-level expression of a desired protein in the mammary gland of a transgenic animal can be achieved while accommodating complex posttranslational modifications. The technique has been successful in producing human ...

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