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Article: Leukotriene receptor antagonist pranlukast suppresses eosinophil infiltration and cytokine production in human nasal mucosa of perennial allergic rhinitis
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- November 1, 2003
- Author:
CopyrightCopyright Annals Publishing Company Nov 2003. Provided by ProQuest LLC. (Hide copyright information)
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The purpose of this study was to investigate the influence of pranlukast on eosinophilic inflammation and cytokine production in human nasal mucosa. Twelve patients were treated with pranlukast, and samples were obtained from the nasal mucosa of the inferior turbinate. With respect to cell infiltration, a significant decrease was observed in the percentage of inflammatory cells (secreted eosinophil cationic protein [EG2] and neutrophil elastase) after treatment. The levels of cytokines and chemical mediators (interleukin [IL]-4, IL-5, RANTES [regulated on activation, normal T cell expressed and secreted], cysteinyl leukotrienes, IL-1[beta], tumor necrosis factor-[alpha], and IL-8) assessed ...