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Article: Overexpression of Fas-ligand in human nasal polyps
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- March 1, 2000
- Author:
CopyrightCopyright Annals Publishing Company Mar 2000. Provided by ProQuest LLC. (Hide copyright information)
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Apoptosis mediated through the Fas/Fas-L system is essential in regulating immune function, developing organs, and conferring immune privilege. To illustrate the role of the Fas/Fas-L system in the pathogenesis of human nasal polyps, we investigated the transcripts and protein level of the Fas-L gene in 8 human nasal polyp tissues and 7 nasal turbinate mucosa specimens using reverse transcription-polymerase chain reaction and Western blotting. Localization of Fas-L was performed with immunohistochemistry. The transcripts of the Fas-L gene were detected at similar levels in both polyps and nasal mucosa. There was a significant overexpression of Fas-L protein on nasal polyps compared to nasal ...