|
|
Article: Novel Hemoglobin Variant [[beta]66(E10) Lys [arrow right] Asn], with Decreased Oxygen Affinity, Causes Falsely Low Hemoglobin A^sub 1c^ Values by HPLC
- Article from:
- Clinical Chemistry
- Article date:
- August 1, 2003
- Author:
CopyrightCopyright American Association for Clinical Chemistry Aug 2003. Provided by ProQuest LLC. (Hide copyright information)
|
The lysine in position 66 of the [beta] chain of hemoglobin (Hb) is located within the heme-binding pocket and is functionally important for oxygen binding (1). The lysine is exceptionally prone to glycation (2) and to modification by advanced glycation endproducts. In this journal, Iwamoto et al. (3) recently proposed an automated immunologic assay for Hb that is specifically advanced glycation endproduct-modified at Lys66.
Here we report on a novel Hb variant at this position [[beta]66(E10) Lys[arrow right]Asn] found in a 73-year-old Caucasian patient with a 9-month history of type 1 diabetes mellitus secondary to recurrent necrotizing pancreatitis and choledocholithiasis. He was referred ...