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Article: ESZOPICLONE

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Formulary
Article date:
December 1, 2003
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Estorra, Sepracor

Cyclopyrrolone

October 2003 Issue

A cyclopyrrolone with potential benefit in transient and chronic insomnia. Benzodiazepines are the gold standard for the treatment of insomnia. However, because of their potential for pharmacologic dependence and withdrawal reactions upon discontinuation, they are neither recommended nor FDA-approved for chronic use. The novel cyclopyrrolone eszopiclone is a stereoselective isomer of the agent zopiclone, which has been available in Europe for more than a decade. Clinical trials in patients with chronic insomnia suggest the medication may help manage both transient and chronic insomnia with minimal side effects. The most commonly reported ...

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