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Article: Light-Induced Byproducts of Vitamin C in Multivitamin Solutions
- Article from:
- Clinical Chemistry
- Article date:
- January 1, 2004
- Author:
CopyrightCopyright American Association for Clinical Chemistry Jan 2004. Provided by ProQuest LLC. (Hide copyright information)
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Background: When solutions of multivitamin preparations (MVPs) are exposed to light, H^sub 2^O^sub 2^ as well as organic peroxides are generated and the concentration of vitamin C decreases. The aim of this study was to determine, using mass spectrometry, whether the generation of oxidative byproducts of vitamin C, such as dehydroascorbate (DHA) and 2,3-diketogulonic acid (DKG), accounted for the reported decrease in ascorbic acid in MVPs exposed to light.
Methods: Mass spectrometry was used to document the formation of byproducts of ascorbic acid in solutions containing a MVP, vitamin C + riboflavin, and vitamin C + H^sub 2^O^sub 2^ + Fe^sup 2+^. The involvement of ascorbic acid and H^sub ...