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Article: Drug--grapefruit juice interactions
- Article from:
- Mayo Clinic Proceedings
- Article date:
- September 1, 2000
- Author:
CopyrightCopyright Mayo Foundation for Medical Education and Research Sep 2000. Provided by ProQuest LLC. (Hide copyright information)
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Grapefruit juice, a beverage consumed in large quantities by the general population, is an inhibitor of the intestinal cytochrome P-450 3A4 system, which is responsible for the first-pass metabolism of many medications. Through the inhibition of this enzyme system, grapefruit juice interacts with a variety of medications, leading to elevation of their serum concentrations. Most notable are its effects on cyclosporine, some 1,4-dihydropyridine calcium antagonists, and some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. In the case of some drugs, these increased drug concentrations have been associated with an increased frequency of dose-dependent adverse effects.
The ...