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Article: ^sup 99m^Tc-MAEC Complexes: New Renal Radiopharmaceuticals Combining Characteristics of ^sup 99m^Tc-MAG3 and ^sup 99m^Tc-EC
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- May 1, 2004
- Author:
CopyrightCopyright Society of Nuclear Medicine May 2004. Provided by ProQuest LLC. (Hide copyright information)
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^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3) and ^sup 99m^Tc-L,L-ethylenedicysteine (^sup 99m^Tc-LL-EC) are useful renal radiopharmaceuticals; however, both agents have renal clearances less than that of ^sup 131^I-orthoiodohippurate (^sup 131^I-OIH), and ^sup 99m^Tc-LL-EC exists in dianionic and monoanionic forms at physiologic pH. In an effort to develop a superior ^sup 99m^Tc agent with a rapid clearance comparable with that of ^sup 131^I-OIH, we have designed a new ligand system, mercaptoacetamide-ethylene-cysteine (MAEC), which combines important structural features of both MAG3 and EC. Methods: Biodistribution and clearance studies were performed on Sprague-Dawley rats ...