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Article: Increased Heme Oxygenase-1 Expression during Copper Deficiency in Rats Results from Increased Mitochondrial Generation of Hydrogen Peroxide1-4
- Article from:
- The Journal of Nutrition
- Article date:
- June 1, 2004
- Author:
CopyrightCopyright American Institute of Nutrition Jun 2004. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
The activity of hepatic heme oxygenase (HO) in rats is elevated in response to copper deficiency. However, the mechanism responsible for the increase in HO activity is poorly understood. Oxidative stress is a common denominator for many of the signals that induce HO-1, the inducible isoform of HO. The present study evaluated the role of H^sub 2^O^sub 2^ and the mitochondrial electron transport chain as a potential mechanism for the induction of HO-1 during copper deficiency. Mitochondria isolated from the livers of young male rats fed a copper-deficient diet for 5 wk had significantly (P < 0.05) reduced levels of NADH:cytochrome c reductase (31% reduction), succinate:cytrochrome ...
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