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Article: Is the Degree of Sensitivity to Nondepolarizing Muscle Relaxants Related to Requirements for Postoperative Ventilation in Patients with Myasthenia Gravis?
- Article from:
- Anaesthesia and Intensive Care
- Article date:
- June 1, 2004
- Author:
CopyrightCopyright Australian Society of Anaesthetists Jun 2004. Provided by ProQuest LLC. (Hide copyright information)
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SUMMARY
The purpose of this study was to examine whether the degree of sensitivity to nondepolarizing muscle relaxants is related to the requirement for postoperative ventilatory support in patients with my asthenia gravis.
Thirty-six patients with myasthenia gravis undergoing trans-sternal thymectomy were monitored by electro-myography in order to assess the neuromuscular response to vecuronium. After calibration to 100% of baseline electromyographic response values using an EMG monitor, incremental doses of 5, 10 and 20 µg/kg of vecuronium were administrated to produce 95% neuromuscular blockade and to obtain a cumulative dose-response curve for each patient. A univariable logistic ...