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Article: IMMUNE-MEDIATED DISORDERS ASSOCIATED WITH IDIOPATHIC SUDDEN SENSORINEURAL HEARING LOSS
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- June 1, 2004
- Author:
CopyrightCopyright Annals Publishing Company Jun 2004. Provided by ProQuest LLC. (Hide copyright information)
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Different immune disorders are involved in the development of sudden sensorineural hearing loss (SSNHL). This includes a wide spectrum of immune-mediated disorders such as immune complexes, production of autoantibodies to the inner ear proteins, production of anticardiolipin (aCL) antibodies, and cellular immune defects. Some studies have also found an elevation of total IgE levels and a type 1 immune reaction. Our objective was to establish the association of "idiopathic" SSNHL (ISSNHL) with various autoantibodies, and to analyze the persistence over time of existing aCL and anti-[beta]2 glycoprotein 1 (anti-[beta]2 GP1) antibodies in such patients. Finally, we sought to establish a ...