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Ipsilateral and contralateral thalamic hypometabolism as a predictor of outcome after temporal lobectomy for seizures

FDG PET is often used to help localize the seizure focus before surgery in patients with medically refractory temporal lobe epilepsy. However, the ability of certain patterns of metabolic landscape to predict postsurgical seizure outcome has not been well characterized. The purpose of this retrospective study was to determine whether FDG PET abnormalities elsewhere in the brain, in combination with those in the temporal lobes, can be used to predict seizure outcome after surgery. Methods: Eighty patients with refractory temporal lobe seizures were imaged with PET after intravenous administration of 115(mu)Ci/kg FDG. Images were interpreted without knowledge of clinical information by an ...

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