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Parametric images of blood flow in oncology PET studies using [(15)O]water
- Article from:
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The Journal of Nuclear Medicine
- Article date:
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November 1, 2000
- Author:
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Copyright informationCopyright Society of Nuclear Medicine Nov 2000. Provided by ProQuest LLC. (Hide copyright information)
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PET was used to measure tumor blood flow, which is potentially valuable for diagnosis and assessing the effects of therapy. To help visualize regional differences in blood flow and to improve the accuracy of region-of-interest placement, a parametric imaging approach was developed and compared with the standard region-of-interest method. Methods: Five patients with renal cell metastases in the thorax were studied using [150]water and dynamic PET To assess the reproducibility of the blood flow measurements, multiple water studies were performed on each patient. Model fitting was done on a pixel-by-pixel basis using several different formulations of the standard single-compartment model. ...
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